MnBn(CO)5-Catalyzed Cascade C-H Activation/Annulation to Construct Bridged N-Heterocycles
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Updated: Oct 31, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Yang Sun1,2, Tiannan Wang1, Nikolaos Kaplaneris3
1School of Pharmacy, Wannan Medical University, Wuhu241002, China.
Abstract:
Herein, a manganese-catalyzed synthesis of bridged heterocycles via a C-H activation/annulation cascade between azomethine imines and Morita-Baylis-Hillman adducts is described. MnBn(CO)5 serves as a highly active catalyst, exhibiting unique and remarkable capability in C-H activation for this transformation. The reaction demonstrates broad substrate scope and good functional group tolerance, providing direct access to bridged pyrazolone frameworks under operationally simple and solvent-free conditions.
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