The complexity of cerebral small vessel disease: In search of the ideal mouse model
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1Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
Abstract:
Currently, there are few animal models that reflect the physiological complexity of cerebral small vessel disease. Ruan et al.1 presented a pericyte-specific knockout of laminin-γ1 that exhibited several key disease-typical characteristic features at 11 months of age.
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