Workup of Encephalopathy in Patients Receiving Cancer Immunotherapy

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Updated: Nov 1, 2026

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
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Quantifying Cognitive Decrements Caused by Cranial Radiotherapy

Published on: October 18, 2011

Neil Sielski1

  • 1NYU Langone Health, Brain & Spine Tumor Center, New York, United States, New York.

Seminars in Neurology
|October 30, 2026
PubMed

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Encephalitis l: Introduction

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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
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