Single-cell profiling reveals systemic immune reprogramming in muscle-invasive urothelial carcinoma
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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Jiazi Cha1, Yufan Yang2, Jinshan Yang2
1Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264100, China; The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, China.
Abstract:
Urothelial carcinoma progression to muscle-invasive disease involves poorly understood systemic immune alterations. We performed single-cell RNA sequencing of peripheral blood mononuclear cells from 20 UC patients, analyzing 144,019 cells with public datasets. MIUC showed profound immune reprogramming: T/NK cells exhibited metabolic stress and suppression, while monocytes exhibited transcriptional features suggestive of pro-tumor reprogramming, potentially involving TGF-β signaling. Enhanced intercellular communication coordinated immunosuppression. These findings reveal stage-specific immune remodeling, providing a foundation for systemic immunotherapies in advanced UC.
