Outcomes of retroperitoneal sarcoma resection: a nine-year retrospective cohort study at a Latin American tertiary center
Related Experiment Video
Updated: Nov 2, 2026
Retzius-Sparing Robot-Assisted Radical Prostatectomy
Published on: May 19, 2022
Juliana Restrepo-López1, Felipe Solórzano1, Hernán Luna-Hurtado2
1Fundación Colombiana de Cancerología Clínica Vida, Carrera 80 # 18 A - 140, Medellín, Colombia.
Purpose:
To evaluate perioperative complications, overall survival (OS), and relapse-free survival (RFS) in patients undergoing resection for retroperitoneal sarcoma (RPS) at a specialized oncology center in Medellín, Colombia.
Methods:
A retrospective cohort study was conducted including 73 patients who underwent curative-intent resection for RPS between 2016 and 2025. Survival probabilities were estimated using the Kaplan-Meier method. Factors associated with OS were evaluated using multivariable Cox proportional hazards regression model.
Results:
The cohort was predominantly female (63.0%), with a median age of 61 years. Liposarcoma was the predominant histological subtype (74.0%), with dedifferentiated (38.4%) and well-differentiated (35.6%) liposarcomas being the most frequent. Compartmental resection was performed in 50.7% of patients. Major postoperative complications (Clavien-Dindo grade ≥III) occurred in 30.1% of cases. At a median follow-up of 24.9 months, the estimated 5-year OS was 56% (95% confidence interval [CI] 45-71) and 5-year RFS was 50.7% (95% CI 39-65). On multivariable analysis, non-well-differentiated liposarcoma histology (hazard ratio [HR] 7.41; 95%CI 2.12-25.87; p=0.002) and intraoperative blood transfusion (HR 4.56; 95%CI 1.49-13.94; p=0.004) were associated with worse OS.
Conclusions:
In this Latin American cohort, non-well-differentiated liposarcoma histology and intraoperative blood transfusion were independent predictors of worse OS following RPS resection. Given the median follow-up of 24.9 months, these survival estimates warrant confirmation in larger multicenter studies.