Wearable Evidence Linking Dyskinesia Burden to Sleep Quality in Parkinson's Disease
Related Experiment Video
Updated: Nov 3, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
Viktoria Azoidou1,2, Essa Bhadra2, Ellen Camboe1,2
1Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Background:
Sleep disturbances affect 60-80% of people with Parkinson's disease (PD) and worsen quality of life. Dyskinesia is a common complication of dopaminergic therapy, yet its link to sleep quality is poorly understood.
Objectives:
To examine whether clinician-rated and objectively measured dyskinesia are associated with sleep quality in PD.
Methods:
We studied 47 people with PD (median age 68 years; 44.7% women; median disease duration 5 years). Sleep was measured with Pittsburgh Sleep Quality Index (PSQI). Dyskinesia was rated clinically (MDS-UPDRS items 4.1, 4.2) and objectively over 7 days using Parkinson's KinetiGraph (median dyskinesia score; DKS). Regression models adjusted for age, sex, motor severity, levodopa dose, and disease duration.
Results:
All dyskinesia measures predicted poorer sleep unadjusted. After adjusting for levodopa dose, only DKS remained significant (B = 0.18, P = 0.047). Adding disease duration attenuated this (P = 0.051).
Conclusions:
Wearable-derived dyskinesia, but not clinician-rated dyskinesia, independently predicted poorer sleep, supporting wearable monitoring in PD.
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