Extracellular Vesicles in Dermatology: Where Are We and What Lies Ahead?
Related Experiment Video
Updated: Nov 3, 2026

Extraction of Extracellular Vesicles from Whole Tissue
Published on: February 7, 2019
Ines Martic1,2, Alessandro Paolini3, Stefania Paola Bruno3
1Institute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria.
Abstract:
Extracellular vesicles (EVs) have emerged as key players in skin biology, mediating intercellular communication across diverse physiological and pathological contexts. In this review, we critically assess the current understanding of EVs in dermatology, highlighting their roles in skin homeostasis, ageing, inflammation, wound healing and cancer. We explore the mechanistic contributions of EVs derived from skin, emphasizing their influence on immune modulation, senescence and tissue regeneration. We also examine their potential as diagnostic biomarkers and therapeutic agents, while addressing key technical and conceptual challenges that limit clinical translation. Drawing on collaborative insights from the COST Action NETSKINMODELS, we provide a set of recommendations to advance the field, including standardizing separation protocols, improving functional characterization and integrating with emerging technologies such as microneedles and 3D bioprinting. Together, these perspectives outline a strategic framework for unlocking the diagnostic and therapeutic potential of EVs in dermatological research and clinical care.
Related Concept Videos
Clinical Applications of Epidermal Stem Cells
Overview of Exosomes
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Intralumenal Vesicles and Multivesicular Bodies
Renewal of Skin Epidermal Stem Cells

