Addressing threats to validity in large dataset research
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Updated: Nov 4, 2026

A User-friendly and Powerful R Analysis of Large-scale Datasets
Published on: November 4, 2025
Wonsuk Yoo1, John P A Ioannidis2,3,4,5
1School of Nursing and Health Studies, Division of Biostatistics/Bioinformatics, Department of Public Health Sciences, TCO Program, Sylvester Comprehensive Cancer Center, University of Miami, Coral Gables, Florida, United States of America.
Abstract:
In this Guidelines and Guidance article, Wonsuk Yoo and John P.A. Ioannidis outline why research using large datasets faces threats to validity, highlighting four main statistical pitfalls and providing guidance and worked examples on how to mitigate against them.
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