SWI/SNF chromatin remodeling complexes in metabolic disorders: integrating tissue-specific epigenetic mechanisms
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Updated: Nov 4, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
Faiz Ur Rahman1, Zong Wei2,3
1Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Scottsdale, AZ, USA.
Abstract:
Metabolic disorders are increasingly linked to epigenetic alterations. SWI/SNF chromatin remodeling complexes have emerged as critical modulators of metabolic homeostasis. In this review, we focus on the tissue-specific biological function of SWI/SNF complexes in the pancreas, liver, adipose tissue, and heart, and highlight the dysregulation of chromatin remodeling in metabolic disease progression. Lastly, we discuss therapeutic opportunities targeting chromatin remodeling mechanisms in metabolic disorders.
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