Ocular Biometric and Fundus Characteristics in High Myopia: Protocol for a Hospital-Based Cross-Sectional Study
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Published on: September 16, 2025
Anshool Kumbhare1, Pranaykumar Shinde1
1Department of Ophthalmology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Wardha, Maharashtra, 442107, India, 91 9834497650.
Background:
High myopia (spherical equivalent refractive error [SER] ≤-6.00 diopters) is a prominent global cause of visual impairment, but its structural alterations are inadequately documented at all severity levels in Indian tertiary hospitals.
Objective:
The aim of this study is to evaluate ocular biometric and fundus traits in high myopia and their relationship to the severity of myopia. The primary outcome is axial length measured using contact A-scan biometry. Meta-Analysis for Pathologic Myopia (META-PM) identified fundus changes, keratometry, central corneal thickness, and refractive astigmatism as secondary outcomes.
Methods:
This hospital-based cross-sectional observational study at Acharya Vinoba Bhave Rural Hospital, India, will enroll 160 participants aged 10 to 50 years with high myopia (SER ≤-6.00 diopters in ≥1 eye) consecutively over 2 years. Ophthalmic examination will include best-corrected visual acuity (converted to logarithm of the minimum angle of resolution [logMAR]), cycloplegic refraction, slit-lamp biomicroscopy, keratometry, pachymetry, A-scan biometry, and dilated fundus examination (META-PM). Statistical analysis will involve the Shapiro-Wilk test, Pearson/Spearman correlation, ANOVA/Kruskal-Wallis, chi-square, and generalized estimating equations using SPSS (version 23; IBM Corp).
Results:
The study received ethics approval on July 9, 2025. Enrollment has been ongoing since January 2026. Results are expected to be published in 2027 or 2028.
Conclusions:
This study will provide region-specific data and guide evidence-based high myopia management.
