Cannulated prolactin test: Useful test to investigate patients with mild hyperprolactinemia?

We discuss the highlights of Matos et al., 2026, publication, which explores the usefulness of the cannulated prolactin test (CPT) when assessing patients with mild hyperprolactinemia. The publication presents data from their own cohort, alongside a pooled analysis of eleven available published series, combining a total of 1,700 patients. The findings support the CPT role in the investigation of mild hyperprolactinemia patients and propose a stepwise approach in which prolactin should be first repeated under optimal (stress-free) conditions, reserving full CPT for those with persistent hyperprolactinemia.