Bupropion-Induced Aseptic Meningitis: Postmarketing Safety Evaluation and Case Report

The U.S. Food and Drug Administration (FDA) evaluated the association between bupropion and aseptic meningitis after detecting a safety signal during routine surveillance. Two cases of aseptic meningitis associated with bupropion were identified, including one exceedingly well-documented case that we assessed with a probable causal association with bupropion. The paucity of cases is striking given the long market duration and widespread utilization of bupropion-containing products. FDA required updates to the U.S. Prescribing Information for bupropion-containing products, as awareness of the rare, possible risk of aseptic meningitis with bupropion may prevent misdiagnosis or hospitalization.