[Neuroleptics and analgesia (author's transl)]

Recent studies have shown that the explanation given for the analgesic effects of neuroleptics based only upon modification of pain interpretation is not valid at the present time. Studies by K. Ramabadran, J. J. C. Jacob, Greese et al., of Leysen and Smee and Overstreet, which take into the account the secretion of endogeneous "ligands" enkephalins and endorphins, offer the possibility of a better approach for understanding the role of neuroleptics in the control of pain. We have attempted to use this interpretation to explain the regular and constant efficacy of tiapride against pain generally and particularly in headaches.