Weight Loss May Improve Outcomes in Ewing Sarcoma Patients
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Published on: December 9, 2016
Yair Peled1, Dror Levin, Michal Manisterski
1Department of Pediatric Hemato-Oncology, Tel Aviv Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Background:
Ewing sarcoma (ES) is an aggressive cancer in which the histologic response to neoadjuvant chemotherapy is a key prognostic factor. This study investigated the correlation between weight loss and chemotherapy response in 57 pediatric patients with ES.
Observation:
A significant, direct correlation (P=0.008) was found between weight loss and a good chemotherapy response: 93% of patients with ≥3% weight loss had a good response, compared with only 40% of those without.
Conclusion:
This may suggest that caloric restriction mimics the effects observed in other cancers, potentially reducing tumor proliferation and angiogenesis.