A Safety Evaluation of D-Glucuronolactone Derived from Inositol

D-glucuronolactone is a natural compound that is a basic structural component of most connective tissues. It has found applications in various products, such as food formulations and cosmetic preparations. As part of safety assessment for this D-glucuronolactone, a series of toxicological tests have been implemented. Acute oral toxicity test showed that no mortality occurred in rats administered up to 10.0 g/kg BW or in mice given up to 20.0 g/kg BW of D-glucuronolactone, classifying it as actual non-toxic. D-glucuronolactone also showed no evidence of genotoxic potential across a range of genotoxicity tests. During 90-day oral toxicity test, there were no adverse findings observed related to the experimental factors, and the no observed adverse effect levels (NOAEL) were 7.66 and 5.61 g/kg BW for females and males. No significant differences in any indicators were indicated in the teratogenicity test between the control group and dose groups, maternal toxicity was absent at all tested doses. The result showed no potential teratogenic or other developmental effects of D-glucuronolactone in rats at the high dose level (5.0 g/kg BW). These findings confirm that D-glucuronolactone is non-toxic, non-genotoxic, well-tolerated at high dose, with no teratogenic effects observed, supporting its safety for use in foods.