Obesity pharmacotherapies and cognition
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Updated: Nov 7, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
Stina Börchers1,2, Giulia Mazzini1, Henrik Zetterberg3,4,5,6,7,8,9
1Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Abstract:
Pharmacotherapies for obesity and type 2 diabetes are increasingly being evaluated for their effects on cognition and brain health. Evidence from preclinical models, observational cohorts, and clinical trials has intensified interest, but findings remain mixed. A central challenge is to determine whether potential cognitive effects arise from direct actions on neural circuits, indirect consequences of improved cardiometabolic health, or both. This Review examines the evidence across cardiometabolic disease, aging, and Alzheimer's disease, focusing on glucagon-like peptide-1 (GLP-1)-based therapies and combination approaches that engage glucose-dependent insulinotropic polypeptide, glucagon, and amylin pathways. We assess how receptor pharmacology, brain exposure, metabolic context, and disease stage shape cognitive outcomes and discuss how mechanistic clarity could guide therapies aimed at preserving or improving cognition.
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