Subventricular Zone As A Hub Of Neocortical Evolution And Development
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Updated: Nov 7, 2026

Cortical Neurogenesis: Transitioning from Advances in the Laboratory to Cell-Based Therapies
Published on: July 19, 2007
Juan C Celis Suescún1, Anastasiia Ermoshina1, Kuo Yan2
1Institute of Neuroscience, Lobachevsky State University of Nizhny Novgorod, Russia.
Abstract:
The Subventricular Zone (SVZ) of the developing neocortex is a secondary proliferative compartment that appeared during mammalian evolution and does not exist in most other vertebrates. It contains mammalian unique types of neural progenitors. In higher mammals with their large and complex neocortex, most neurons are generated in the SVZ. The development and primate specific diversification of SVZ is controlled by evolutionary new genes. On the other hand, the SVZ is the main hub where many aspects of the neuronal differentiation are commenced, including cell fate specification, axon determination and guidance, as well as interneuron migration. In this review, we will discuss findings in the field about the role of SVZ in the development of the neocortex, as well as its impact on neocortical evolution.
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