The interaction between GPCR and Na+ channels via Go proteins in excitable cells
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Updated: Nov 7, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
Published on: February 20, 2018
1Gray Faculty of Medicine and Health Sciences & Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel. marmon@tauex.tau.ac.il.
Abstract:
Our findings in excitable cells support the recent work of Kim et al. (Exp Mol Med 57:2717-2728, 2025), which describes a direct interaction between ion channels and G proteins. We identified a direct interaction between muscarinic receptors, voltage-dependent sodium channels (VDSC), and Go proteins in mammalian excitable cells. Their interaction was dependent on the opening of the VDSC pore, and it implicated modifications in the VDSC transmembrane S6 segments that orchestrate the channel pore opening in coordination with the VDSC voltage sensors.
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