Electroenzymatic Sequential Catalysis for Enantiodivergent Synthesis of Halohydrins
Xiao-Jian Zhou1, An-Ni Wang1, Da-Li Shi1
1Key Laboratory of Innovation and Manufacturing for Pharmaceuticals of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi563006, China.
Abstract:
Chiral halohydrins are valuable synthetic intermediates. Herein, we report an electroenzymatic sequential catalysis strategy for the site-selective and enantiocomplementary C-H hydroxylation of functionalized alkylarenes, enabling facile access to chiral halohydrins, methyl mandelate, and β-nitro alcohol under mild conditions with favorable yields and excellent enantioselectivity. The system also enables β-chlorohydrin deracemization, broadening the synthetic scope of enantiopure functionalized benzyl alcohols and offering a practical alternative to conventional methods.
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