Activating photodynamic therapy via thionation: croconaine nanoparticles for NIR light-mediated PDT/PTT
Related Experiment Video
Updated: Nov 8, 2026
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Kanchan Negi1, Gourav Chakraborty1, Sushmita Patra2
1Department of Chemistry and Chemical Biology, Indian Institute of Technology (ISM), Dhanbad 826004, Jharkhand, India. sksahu@iitism.ac.in.
Abstract:
A simple molecular engineering strategy activated photodynamic therapy in the croconaine core via sulphur-for-oxygen substitution, thereby enhancing intersystem crossing and singlet oxygen generation. Self-assembled thionated croconaine nanoparticles exhibited high photostability, 21.65% singlet oxygen quantum yield, 35.57% photothermal conversion efficiency, and effective synergistic near-infrared photodynamic/photothermal cancer therapy.
