Improved Access to Succinimide-Fused Cyclobutenes
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Updated: Nov 8, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Xiaojing Hou1, Xinru Zhang1, Jiaxi Xu1
1College of Chemistry, Beijing University of Chemical Technology, 15 Beisanhuan East Rd, Chaoyang, Beijing100029, P. R. China.
Abstract:
Succinimide-fused cyclobutenes are valuable building blocks for the synthesis of highly functionalized polycyclic structures. However, methods for constructing these structures-especially the N-aryl ones-remain limited. Herein, we provided an improved and rapid access to N-substituted succinimide-fused cyclobutenes by leveraging the copper-catalyzed Chan-Lam coupling. Desired products are afforded in 45-99% yields. Furthermore, this method features a broad substrate scope and good functional group compatibility.
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