The immune code of metal-dependent cell death
Jiao Liu1, Daolin Tang2, Rui Kang2
1DAMP Laboratory, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Trends in Immunology
|November 6, 2026
Abstract:
Metal-dependent cell death can provoke, suppress, or evade immune recognition. We propose that these divergent outcomes reflect two interacting sources of information: signals generated by dying cells and changes in metal availability and localization that shape their perception. Their integration, rather than the death pathway alone, may determine immunogenicity.
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