[Hypercholesterolemia and lipid profile alterations in Moroccan patients with myocardial infarction: A case-control study]
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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
K Mohammadi1, C Jramy2, W Adadi1
1Laboratory of Biotechnology, Agri-Food, Materials and Environment, LBAME URAC36, Hassan II University of Casablanca, 20650 Casablanca, Maroc.
Background:
Hypercholesterolemia, particularly elevated low-density lipoprotein cholesterol (LDL-C), is a major risk factor for cardiovascular diseases, including myocardial infarction.
Aims:
This study aimed to investigate lipid profile alterations in Moroccan patients with myocardial infarction.
Methods:
This case-control study included 104 patients hospitalized for myocardial infarction at the Ibn Rochd University Hospital Center (mean age: 59±11 years; range: 30-82 years) and 79 apparently healthy controls recruited at the Pasteur Institute of Casablanca (mean age: 48±8 years; range: 23-57 years). Serum total cholesterol (TC), triglycerides (TG), LDL-C, and high-density lipoprotein cholesterol (HDL-C) were measured using standardized enzymatic methods.
Results:
Patients with myocardial infarction exhibited significantly higher levels of TC, TG, and LDL-C compared with controls, with increases of 17.5% (P<0.001), 78.2% (P<0.001), and 27.7% (P<0.001), respectively. In contrast, HDL-C levels were significantly reduced by 22.2% in patients with myocardial infarction (P<0.001).
Conclusion:
These findings highlight a strong association between dyslipidemia and myocardial infarction in the Moroccan population, emphasizing the importance of lipid profile monitoring for cardiovascular risk prevention.
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