Olfactory neuroepithelium biomarker platform: a proof from Alzheimer's disease
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Updated: Nov 9, 2026

A Free-breathing fMRI Method to Study Human Olfactory Function
Published on: July 30, 2017
Abstract:
Unlike other diseases where target organs for biopsy are accessible, surrogate platforms are warranted for biomarkers of neuropsychiatric disorders due to the inaccessibility of the brain. We demonstrate a non-invasive platform combining a nasal soft-brush swab with single-cell Western blotting for neuron-specific protein analysis. Applied to Alzheimer's disease targeting phosphorylated tau, this demonstrated superior diagnostic capacity compared with blood-based approaches, indicating that the olfactory neuroepithelium is a sensitive biomarker platform.
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