Relationship Between Preoperative PET-CT SUVmax Values and Solid Component in Endometrioid Type Endometrial Cancer
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Ibrahim Guven1, Görkem Ulger2, Hamza Yildiz3
1Department of Obstetrics and Gynecology, Mersin University Faculty of Medicine, Mersin, Turkey.
Purpose:
To evaluate the relationship between preoperative PET-CT SUVmax values and tumor solid component ratio in endometrioid type endometrial cancer patients.
Methods:
This retrospective study included 53 patients with endometrioid type endometrial cancer who underwent surgery between January 2018 and January 2024. All patients had preoperative PET-CT imaging. Clinicopathological features, SUVmax values, and solid component ratios were analyzed. Statistical analysis included correlation analysis and ROC curve analysis.
Results:
The median SUVmax value was 22.0 (4.4-66.5) and median solid component ratio was 2.0% (1-99%). SUVmax values showed significant correlations with tumor grade (p = 0.012), myometrial invasion depth (p = 0.035), tumor size (p = 0.009), and LVSI status (p = 0.034). A significant positive correlation was found between SUVmax values and solid component ratio (r = 0.359, p = 0.008). ROC analysis revealed that SUVmax > 29 could predict Grade 3 tumors with 83.33% sensitivity and 81.25% specificity (AUC = 0.851).
Conclusions:
Preoperative PET-CT SUVmax values correlate significantly with important prognostic factors including solid component ratio in endometrioid type endometrial cancer. These findings suggest that SUVmax could serve as a valuable biomarker for risk stratification and treatment planning.