Left Ventricular Aneurysm Associated With Severe Aortic Regurgitation
Related Experiment Video
Updated: Nov 9, 2026

Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse
Published on: August 30, 2022
Fen Sa1, Kai Yang1, Xiuyu Chen1
1Department of Radiology, Fuwai Hospital, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Images:
Multimodality imaging findings.
Case Summary:
A 53-year-old man presented with exertional chest tightness. Transthoracic echocardiography showed severe aortic regurgitation, left ventricular dilatation, basal inferior wall thinning with paradoxical motion, and an eccentric regurgitant jet impinging on the basal inferior wall. Coronary computed tomography angiography excluded obstructive disease. Cardiovascular magnetic resonance demonstrated an inferior aneurysm with near-transmural late gadolinium enhancement. Four-dimensional flow imaging further characterized the regurgitant jet trajectory, with a localized vortex and elevated wall shear stress. He underwent bioprosthetic aortic valve replacement.
Take-Home Message:
Multimodality imaging demonstrated spatial concordance between eccentric regurgitant flow, regional hemodynamic abnormalities, and myocardial injury.
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