GallMine: an integrated knowledgebase and data repository on gallbladder cancer

Gallbladder cancer (GBC) is a rare but aggressive hepatobiliary malignancy associated with high mortality rates. It has multi-factorial etiology with a poor diagnosis and prognosis. Despite aggressive disease phenotype, GBC treatment options remain limited mostly due to inadequate scientific understanding and data. Here, we present "GallMine" ( https://www2.tezu.ernet.in/gallmine/ ), an interactive knowledgebase that systematically integrates widely scattered and unstructured scientific information on GBC into a unified repository organized across multiple tabs. GallMine encompasses information on eight GBC transcriptome datasets, along with differential expression profiles and curated data for 1,423 tumor-specific genes and 337 lncRNAs, alongside 459 and 54 GBC-specific proteins and metabolite signatures, respectively. Users can browse, download, and contribute information on GBC-associated genes, lncRNAs, proteins, and metabolites. Additionally, GallMine incorporates curated content from 301 published literature, comprising 124 multi-omics studies on GBC, 60 studies on gallstone disease, 40 on the clinical and molecular profiles of GBC across diverse sample types, and 77 focused on its risk factors. GallMine serves as a consolidated resource containing structured information on GBC. It serves as a hub for large-scale computational analysis of molecular signatures critical for GBC pathogenesis, supporting AI/ML data integration and training, biomarker discovery, and improved therapeutic interventions. In subsequent versions GallMine may be expanded to include information on other gallbladder-related diseases.