Developing the World-Wide FINGERS biorepository for dementia risk reduction trials
Related Experiment Video
Updated: Nov 10, 2026
Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
Anna Matton1,2,3,4, Chinedu Udeh-Momoh1,5,6, Makrina Daniilidou1,2,3
1FINGERS Brain Health Institute, Stockholm, Sweden.
Introduction:
Dementia prevention research increasingly uses multimodal interventions. Harmonized biomarker practices are essential to enable comparable cross-population analysis with initiatives such as the World-Wide FINGERS (WW-FINGERS) network contributing to this effort.
Methods:
To advance globally representative biomarker research in dementia prevention trials, we conducted a cross-sectional, network-wide survey of WW-FINGERS teams assessing biospecimen collection, processing and storage, biomarker measurements, and readiness for harmonized procedures.
Results:
Most studies (30/39) had or were developing biorepositories; four planned collection and five had none. Practices were broadly aligned, but remaining variability highlights priority targets for harmonization. Clinical biomarkers (lipids, glucose, liver/kidney function) were obtained even in lower-resourced settings. Many studies measured Alzheimer's disease and related dementias (ADRD) biomarkers (blood-based amyloid/tau and neurodegeneration; cerebrospinal fluid where feasible) and increasingly used multi-omics platforms. Evidence-based preanalytical guidance were provided.
Conclusion:
The WW-FINGERS biorepository provides a world-first platform for harmonized biomarker discovery across diverse populations in dementia prevention, helping to reduce inequities in research participation, accelerating globally representative strategies.
