[Causal relationship between periodontal disease and prostate cancer: A two-sample bidirectional Mendelian randomization analysis in two races]

Objective The aim of this study is to discuss the causal relationship between periodontal disease (PD) and prostate cancer (PCa). Methods A two-sample bidirectional Mendelian randomization (MR) analysis based on publicly statistical data from genome-wide association studies (GWAS) was conducted. MR Egger, weighted medium, simple mode and weighted mode were supplemented, while inverse variance weighted analysis (IVW) was the main method of analysis. Heterogeneity testing, pleiotropy testing and leave-one-out testing were used to assess the sensitivity and stability. Results The results of MR analysis showed that PD had no significant impact on the occurrence of PCa: East Asian (IVW, PD: OR=1.07, P=0.48); European (IVW, PD: OR=1.00, P=0.37, periodontitis: OR=1.03, P=0.14, chronic gingivitis: OR=0.99, P=0.37, chronic periodontitis: OR=1.03, P=0.22). The reverse MR analysis also did not show a causal relationship between PCa and PD: East Asian (IVW, PD: OR=0.97, P=0.22); European (IVW, PD: OR=0.84, P=0.44, periodontitis: OR=1.01, P=0.75, chronic gingivitis: OR=0.93, P=0.23, chronic periodontitis: OR=0.99, P=0.80). The results of other analysis were consistent with those of IVW analysis. Conclusions The results of our two-sample bidirectional MR analysis do not support a causal relationship between PD and PCa.