Persistent Severe OSA Despite Ongoing CPAP Therapy
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Updated: Nov 11, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Elisa Perger1, Francesca Paolelli2, Federico Leone3
1Istituto Auxologico Italiano, IRCCS, Milan, Italy; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Case Presentation:
A 51-year-old man was referred to our sleep medicine clinic for reevaluation of previously diagnosed OSA. The diagnosis had been established approximately 4 years earlier, at a body weight of 105 kg (BMI, 31.7 kg/m2). At that time, cardiorespiratory polygraphy documented severe OSA, with an apnea-hypopnea index of 97 events/h. Mean nocturnal oxygen saturation (Spo2) was 91%, and the cumulative time spent with Spo2 < 90% accounted for 38% of the total recording time, indicating a substantial nocturnal hypoxemic burden. Nocturnal CPAP therapy had been prescribed, delivered through an oronasal mask at a fixed pressure of 11 cm H2O.
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