Synthetic Biology-Based Biomanufacturing: Current Status and Future Prospects

Biomanufacturing, which utilizes biological systems to produce chemicals, pharmaceuticals, and materials, has undergone transformative changes in recent decades, evolving from traditional genetic engineering-based production systems to new platforms based on synthetic biology. This chapter provides an in-depth overview of the development of biomanufacturing under the influence of synthetic biology and discusses various tools and strategies of artificial intelligence for pathway design, construction, and optimization, which play a crucial role in overcoming the limitations of traditional methods. However, data barriers, insufficient model interpretability, and generalizability challenges remain the current major bottlenecks. In the future, with interdisciplinary integration and technological iteration, synthetic biology will drive the evolution of biomanufacturing towards a sustainable bioeconomy, ultimately forming a new paradigm of green and low-carbon industrial production.