Linear Psoriasis with Postzygotic Loricrin Mutation Successfully Treated with Secukinumab
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Updated: Nov 12, 2026
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Youcong Wang1, Li Zhang1, Jie Zheng1
1From the Department of Dermatology, School of Medicine, Rui Jin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Indian Journal of Dermatology
|November 11, 2026
Abstract:
Linear psoriasis is a rare variant of psoriasis, and there are few reports on its pathogenesis. We report a case of linear psoriasis successfully treated with secukinumab. Whole-exome sequencing and immunofluorescence staining revealed that the patient's condition was caused by a mutation in loricrin.