[Sphingolipid metabolism and male reproductive function:Progress in research]
Related Experiment Video
Updated: Nov 12, 2026

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
Published on: December 23, 2022
1Department of Andrology, Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine, Wuxi, Jiangsu 214071, China.
Abstract:
Sphingolipids are not only important components of cell membranes but also regulate key physiological processes such as apoptosis, autophagy, sperm capacitation, and acrosome reaction of spermatogenic cells through their metabolic products. These processes are closely related to sperm production and normal fertilization. Exploring the relationship between sphingolipid metabolism and male reproduction not only helps to reveal the pathological mechanisms of infertility but also may provide new targets for clinical treatment. This review systematically summarizes the role of sphingolipid metabolism in male reproduction and its potential mechanisms, covering the physiological and pathological mechanisms of sphingolipid metabolism and male reproductive function, the mechanisms by which sphingolipid metabolism is affected by physical and chemical factors on reproductive function, and the intervention of sphingolipid metabolism by traditional Chinese medicine and new drugs, aiming to provide new ideas for the diagnosis and treatment of male infertility.
Related Concept Videos
Infertility in Males
Testosterone: Functions and Regulation
Spermatogenesis
Cirrhosis I: Introduction
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Overview of Fatty Acid Metabolism
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...