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Inverted papilloma and squamous cell carcinoma.
The Journal of Otolaryngology
|April 1, 1979
Summary
Inverted papilloma of the nose and sinuses frequently harbors squamous cell carcinoma, a premalignant lesion. Early detection through meticulous pathology and radical surgery are crucial for patient survival.
Area of Science:
- Otolaryngology
- Pathology
- Oncology
Background:
- Inverted papilloma (IP) is a benign sinonasal tumor.
- Malignant transformation of IP to squamous cell carcinoma (SCC) is a known but infrequent complication.
Purpose of the Study:
- To determine the incidence of SCC in IP specimens.
- To evaluate the clinical outcomes of patients with IP and SCC.
Main Methods:
- Retrospective review of 15 patients with histologically confirmed IP.
- Analysis of pathological specimens for evidence of SCC.
- Surgical treatment via lateral rhinotomy with sinus exenteration.
Main Results:
- Eight of 15 patients (53%) had SCC in their IP specimens.
- Four patients died of SCC.
- The observed SCC incidence significantly exceeds previously reported rates (7-24%).
Conclusions:
- Meticulous microscopic examination of multiple sections is essential for detecting SCC in IP.
- IP should be considered a premalignant lesion requiring radical surgical management.