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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

[State of the kallikrein-kinin system in chronic circulatory insufficiency]

V V Murashko, A V Strutynskii, O M Abdel Karim

    Kardiologiia
    |March 1, 1979
    PubMed

    Insights

    Chronic circulatory insufficiency activates the kinin system, indicated by reduced plasma prekallikrein. Cardiac glycoside treatment normalized kinin system indices alongside clinical improvement.

    Area of Science:

    • Biochemistry
    • Cardiology
    • Pharmacology

    Background:

    • The kallikrein-kinin system plays a role in cardiovascular function.
    • Chronic circulatory insufficiency is a complex condition affecting hemodynamics.
    • Understanding the kallikrein-kinin system's involvement may reveal therapeutic targets.

    Purpose of the Study:

    • To investigate the kallikrein-kinin system's status in patients with chronic circulatory insufficiency.
    • To evaluate the impact of cardiac glycosides on the kallikrein-kinin system in these patients.

    Main Methods:

    • Studied 93 patients with chronic circulatory insufficiency.
    • Assessed plasma prekallikrein and kallikrein inhibitor levels.
    • Analyzed changes in 25 patients before and after cardiac glycoside treatment, monitoring central hemodynamics.

    Main Results:

    • All patients exhibited significant activation of the kinin system, evidenced by decreased plasma prekallikrein and altered kallikrein inhibitor levels.
    • Clinical improvement and enhanced central hemodynamics correlated with normalization of kinin system indices.
    • Patients intolerant to cardiac glycosides did not show restoration of kinin system components.

    Conclusions:

    • The kallikrein-kinin system is activated in chronic circulatory insufficiency.
    • Cardiac glycoside therapy can normalize kinin system function in conjunction with clinical improvement.
    • Kinin system normalization may be a marker of successful cardiac glycoside treatment.

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