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Related Experiment Videos

Endocardial alterations in myocardial infarction.

R C Johnson, R S Crissman, L J DiDio

    Laboratory Investigation; a Journal of Technical Methods and Pathology
    |February 1, 1979
    PubMed
    Summary

    In canine hearts with transmural infarcts, the endocardium showed significant alterations, including endothelial cell shedding and leukocyte invasion, indicating an inflammatory response. These changes were consistently observed in infarcted areas, highlighting the endocardial manifestation of myocardial injury.

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    Area of Science:

    • Cardiovascular Pathology
    • Myocardial Infarction Research
    • Endothelial Biology

    Background:

    • Transmural infarcts damage the left ventricle's ventrolateral wall.
    • The endocardium's response to myocardial infarction is not fully understood.

    Purpose of the Study:

    • To investigate the structural changes in the endocardium following left ventricular transmural infarction.
    • To characterize the endocardial manifestation of the inflammatory stage of myocardial infarction.

    Main Methods:

    • Canine left ventricle transmural infarcts created by coronary artery ligation.
    • Endocardial sampling at infarct center, periphery, and normal areas at 24 and 48 hours.
    • Correlative scanning/transmission electron microscopy and light microscopy.

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  • Sham-ligated hearts used as controls.

    • Main Results:

    • Endothelial desquamation and leukocytic invasion observed in infarcted endocardium.
    • Leukocytes initiated endothelial cell sloughing, leaving denuded basal lamina.
    • Subendothelial surfaces rarely showed thrombi.
    • Leukocytic exudate present in subjacent myocardium and endocardium.

    Conclusions:

    • The endocardium undergoes significant alterations during the inflammatory stage of transmural myocardial infarction.
    • Leukocyte infiltration plays a key role in endocardial damage.
    • These findings correlate electron microscopy observations with infarct topography.