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Overgrowth stimulating factor released from Rous sarcoma cells.

H Rubin

    Science (New York, N.Y.)
    |February 27, 1970
    PubMed
    Summary
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    Researchers identified a nonviral factor from Rous sarcoma cells that promotes rapid and sustained cellular overgrowth in chick embryo cultures. This growth factor is released after cell transformation.

    Area of Science:

    • Cell Biology
    • Virology
    • Biochemistry

    Background:

    • Rous sarcoma virus (RSV) infection causes cellular transformation in chick embryos.
    • Understanding the mechanisms behind RSV-induced cellular overgrowth is crucial.

    Purpose of the Study:

    • To describe an assay for a nonviral factor stimulating cellular overgrowth.
    • To characterize the properties of this growth-promoting factor.

    Main Methods:

    • Assay development for detecting cellular overgrowth in crowded chick embryo cultures.
    • Characterization of the factor's properties (nondialyzable, thermolabile).

    Main Results:

    • A nonviral factor was identified in the medium of Rous sarcoma cells.

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  • This factor stimulates rapid and sustained cellular overgrowth.
  • The factor is nondialyzable and thermolabile.
  • It is released several days post-infection, following visible cell transformation.

    • Conclusions:

    • A novel nonviral factor contributes to RSV-induced cellular overgrowth.
    • This factor's properties suggest a role in the complex transformation process.