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Inactivation of vesicular stomatitis virus by disinfectants
Applied Microbiology
|January 1, 1970
Summary
Twenty-four chemical disinfectants were evaluated for virucidal activity against vesicular stomatitis virus. Some disinfectants, including substituted phenols and acids, were effective, while basic compounds were not.
Area of Science:
- Microbiology
- Virology
- Infectious Diseases
Background:
- Chemical disinfectants are crucial for controlling viral infections.
- Understanding the efficacy of various disinfectants against specific viruses is essential for public health.
- Vesicular stomatitis virus (VSV) serves as a model for studying enveloped viruses.
Purpose of the Study:
- To assess the virucidal efficacy of 24 chemical disinfectants against vesicular stomatitis virus.
- To determine the inactivation kinetics of selected disinfectants.
- To identify effective and ineffective disinfectant classes for VSV.
Main Methods:
- Twenty-four chemical disinfectants were screened for virucidal activity.
- Quantitative inactivation experiments were performed using specific disinfectants.
- Inactivation kinetics were determined for acid, alkaline, and substituted phenolic disinfectants.
- Vesicular stomatitis virus (VSV) with a high titer (LD(50) of 10(8.5) virus units/0.1 ml) was used.
Main Results:
- Ten of the tested disinfectants failed to inactivate VSV within 10 minutes at 20°C.
- Substituted phenolic disinfectants, halogens, cresylic acid, and hydrochloric acid demonstrated virucidal activity.
- Basic compounds, including lye and sodium metasilicate, were found to be non-virucidal.
Conclusions:
- The virucidal effectiveness of chemical disinfectants varies significantly.
- Substituted phenols, halogens, and certain acids are effective against vesicular stomatitis virus.
- Basic compounds are not effective virucides for this virus, highlighting the importance of disinfectant selection.
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