Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypothalamic-pituitary-gonadal dysfunction in men using cimetidine.

D H Van Thiel, J S Gavaler, W I Smith

    The New England Journal of Medicine
    |May 3, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The "pseudo-cholangiocarcinoma sign" in patients with cavernous transformation of the portal vein and its effect on the serum alkaline phosphatase and bilirubin levels.

    The American journal of gastroenterology·1995
    Same author

    Treatment of hepatitis C virus in elderly persons with interferon alpha.

    The journals of gerontology. Series A, Biological sciences and medical sciences·1995
    Same author

    Retraction. Successful treatment of end stage liver disease due to hepatitis C prior to liver transplantation.

    Hepatology (Baltimore, Md.)·1995
    Same author

    Utility of hepatitis C virus RNA determinations in hepatic tissue as an end point for interferon treatment of chronic hepatitis C.

    Hepatology (Baltimore, Md.)·1995
    Same author

    Source of oxygen free radicals produced by rat hepatocytes during postanoxic reoxygenation.

    Biochimica et biophysica acta·1995
    Same author

    The use of interferon for the treatment of viral hepatitis in pediatric liver transplant recipients.

    The Journal of the Oklahoma State Medical Association·1995
    Same journal

    Ebola at 50 - Lessons for Outbreak Response and Preparedness.

    The New England journal of medicine·2026
    Same journal

    Ianalumab plus Eltrombopag in Immune Thrombocytopenia. Reply.

    The New England journal of medicine·2026
    Same journal

    Ianalumab plus Eltrombopag in Immune Thrombocytopenia.

    The New England journal of medicine·2026
    Same journal

    Hypertension Control in Low-Income Patients. Reply.

    The New England journal of medicine·2026
    Same journal

    Hypertension Control in Low-Income Patients.

    The New England journal of medicine·2026
    Same journal

    Hypertension Control in Low-Income Patients.

    The New England journal of medicine·2026
    See all related articles

    Cimetidine therapy significantly reduced sperm count and luteinizing hormone response in men. Prolonged use of this medication requires caution due to potential impacts on the hypothalamic-pituitary-gonadal axis.

    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Pharmacology

    Background:

    • Cimetidine is a histamine H2 receptor antagonist.
    • Its effects on the male reproductive system are not fully understood.

    Purpose of the Study:

    • To investigate the impact of cimetidine on the hypothalamic-pituitary-gonadal axis in men.

    Main Methods:

    • Seven healthy men received cimetidine (1200 mg/day) for nine weeks.
    • Hormonal levels and responses to stimulation tests were assessed.

    Main Results:

    • A 43% mean reduction in sperm count was observed.
    • Luteinizing hormone response to GnRH was reduced.
    • Testosterone levels showed a statistically significant rise but remained lower than baseline.

    Related Experiment Videos

  • Gonadotropin responses to clomiphene were inadequate compared to controls.

    • Conclusions:

    • Cimetidine therapy can negatively affect male reproductive function.
    • Caution is advised for prolonged cimetidine use in young men.
    • Further research is needed to elucidate the mechanisms involved.