Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sleep and hypnotics: further experiments.

J I Evans, O Ogunremi

    British Medical Journal
    |August 8, 1970
    PubMed
    Summary
    This summary is machine-generated.

    Chloral hydrate, dichloral phenazone, and Mandrax were tested for their effects on sleep. Chloral hydrate notably reduced REM sleep, unlike the other drugs, with no withdrawal rebound observed.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evaluation of excretory-secretory products and somatic worm antigens for the serodiagnosis of experimental Parelaphostrongylus tenuis infection in white-tailed deer.

    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2003
    Same author

    Purification of first-stage larvae of Elaphostrongylus cervi (Nematoda: Protostrongylidae) from feces.

    The Journal of parasitology·2001
    Same author

    Serological diagnosis of Parelaphostrongylus tenuis infection in white-tailed deer and identification of a potentially unique parasite antigen.

    The Journal of parasitology·1999
    Same author

    Distinct immunological states in murine cutaneous leishmaniasis by immunising with different amounts of antigen: the generation of beneficial, potentially harmful, harmful and potentially extremely harmful states.

    Behring Institute Mitteilungen·1997
    Same author

    Towards a strategy of universally efficacious vaccination against pathogens uniquely susceptible to cell-mediated attack.

    Journal of biotechnology·1996
    Same author

    Genetics of resistance to Trypanosoma congolense in inbred mice: efficiency of apparent clearance of parasites correlates with long-term survival.

    The Journal of parasitology·1995
    Same journal

    Muscular pain during therapy with carbenoxolone (Biogastrone).

    British medical journal·2016
    Same journal

    ACUTE INTESTINAL OBSTRUCTION DUE TO INTRA-ABDOMINAL CAUSES.

    British medical journal·2014
    Same journal

    A CASE OF HAEMATIDROSIS.

    British medical journal·2014
    Same journal

    Incidence of ulcer in haematemesis.

    British medical journal·2011
    Same journal

    Pituitary hypothyroidism with impaired renal function.

    British medical journal·2011
    Same journal

    The fenestration operation for otosclerosis.

    British medical journal·2011
    See all related articles

    Area of Science:

    • Pharmacology
    • Sleep Medicine
    • Neuroscience

    Background:

    • Clinical doses of amylobarbitone are known to affect sleep patterns.
    • Investigating the impact of other sedatives on sleep is crucial for understanding their therapeutic potential and side effects.

    Purpose of the Study:

    • To evaluate the effects of chloral hydrate, dichloral phenazone, and Mandrax on Rapid Eye Movement (REM) sleep.
    • To determine if these hypnotics cause REM sleep rebound upon withdrawal.
    • To explore the concept of a hypnotic dose threshold for REM sleep reduction.

    Main Methods:

    • Two experiments were conducted using healthy male subjects over 6-8 weeks.
    • Subjects received placebo or drugs (chloral hydrate, dichloral phenazone, Mandrax) during controlled periods.

    Related Experiment Videos

  • Sleep patterns, specifically REM sleep, were monitored, along with withdrawal effects.

    • Main Results:

    • Chloral hydrate significantly depressed REM sleep, though less consistently than amylobarbitone, with no observed withdrawal rebound.
    • Dichloral phenazone and Mandrax did not consistently depress REM sleep.
    • Mandrax showed a higher incidence of occasional low REM sleep nights compared to dichloral phenazone.

    Conclusions:

    • A potential dose threshold for hypnotic drugs exists, above which REM sleep reduction occurs.
    • Chloral hydrate may be clinically useful with a lower risk of withdrawal effects compared to other tested hypnotics.
    • Further research may enable the prescription of effective hypnotics while minimizing adverse withdrawal symptoms.