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Plasma 11-hydroxycorticoid levels after carbenoxolone sodium
British Medical Journal
|August 29, 1970
Summary
Carbenoxolone sodium increases plasma 11-hydroxycorticoid levels in patients with duodenal ulcers. This suggests carbenoxolone directly stimulates the adrenal cortex, boosting corticosteroid production.
Area of Science:
- Endocrinology
- Pharmacology
Background:
- Duodenal ulcers are a common gastrointestinal condition.
- Corticosteroids play a crucial role in regulating various bodily functions.
Purpose of the Study:
- To investigate the effect of carbenoxolone sodium on plasma 11-hydroxycorticoid levels.
- To explore the mechanism of action of carbenoxolone sodium on corticosteroid production.
Main Methods:
- Oral administration of carbenoxolone sodium to patients with duodenal ulcer.
- Measurement of plasma 11-hydroxycorticoid levels.
- Observation of corticosteroid response in patients with suppressed pituitary ACTH secretion and adrenal insufficiency.
Main Results:
- A significant increase in plasma 11-hydroxycorticoid levels was observed in eight patients with duodenal ulcer after carbenoxolone sodium administration.
- A similar rise was noted in one sarcoidosis patient with dexamethasone-suppressed ACTH.
- No significant rise was observed in three patients with adrenal insufficiency.
Conclusions:
- Carbenoxolone sodium appears to directly stimulate the adrenal cortex.
- This stimulation leads to increased corticosteroid production, as evidenced by elevated plasma 11-hydroxycorticoid levels.