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Serological studies with human papova (wart) virus.

M M Ogilvie

    The Journal of Hygiene
    |September 1, 1970
    PubMed
    Summary

    Passive haemagglutination is a highly sensitive method for detecting antibodies to wart virus, even years after infection or in individuals unaware of prior exposure. This technique also identified shared antigens across different wart types.

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    Area of Science:

    • Immunology
    • Virology

    Background:

    • Antibodies to wart virus play a role in disease resolution.
    • Previous methods for detecting these antibodies had limitations.

    Purpose of the Study:

    • To compare the sensitivity of different methods for detecting antibodies to wart virus.
    • To investigate the duration of antibody presence and antigenic relationships between wart viruses.

    Main Methods:

    • Comparison of complement fixation, passive haemagglutination, and precipitin tests.
    • Analysis of sera from individuals with a history of warts.

    Main Results:

    • Passive haemagglutination demonstrated superior sensitivity, especially for detecting immunoglobulin M antibodies.
    • Antibodies were detected in individuals with resolved warts and even those unaware of past infections.
    • Antigenic identity was observed between viruses from hand, plantar, and genital warts.

    Conclusions:

    • Passive haemagglutination is a highly effective method for wart virus antibody detection.
    • Wart virus antibodies can persist for years, indicating long-term immune response.
    • A common antigen exists among various human wart virus types.

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