Binding and kinetic studies of liver alcohol dehydrogenase-coenzyme-pyrazole complexes

Resolution of Michaelis complex, acylation, and conformational change steps in the reactions of the serpin, plasminogen activator inhibitor-1, with tissue plasminogen activator and trypsin.

Biochemistry·2001

The distal hinge of the reactive site loop and its proximity: a target to modulate plasminogen activator inhibitor-1 activity.

The Journal of biological chemistry·2001

Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.

The Journal of biological chemistry·2000

Accelerated conversion of human plasminogen activator inhibitor-1 to its latent form by antibody binding.

The Journal of biological chemistry·1999

Inhibitory mechanism of serpins: loop insertion forces acylation of plasminogen activator by plasminogen activator inhibitor-1.

Biochemistry·1998

Characterization of the binding of different conformational forms of plasminogen activator inhibitor-1 to vitronectin. Implications for the regulation of pericellular proteolysis.

The Journal of biological chemistry·1997

The BAIAP2 Pathway Regulates Proliferation and Migration in Medulloblastoma.

The Journal of biological chemistry·2026

Targeting PGAM1 Y119 Phosphorylation Resensitizes Non-Small Cell Lung Cancer to Cisplatin Therapy by Promoting Oxidative Stress and DNA Damage.

The Journal of biological chemistry·2026

M6PR/IGF2R double-knockout supplies therapeutic sources for mucolipidosis II and Niemann-Pick C2.

The Journal of biological chemistry·2026

ZBTB38 requires an extended N-terminal zinc finger network to read mCpG- and discriminate TpG-containing DNA sequences.

The Journal of biological chemistry·2026

In vitro reconstitution implicates multiple OMP assembly factors in CdiAEC93 toxin delivery.

The Journal of biological chemistry·2026

Hepatic stearoyl-CoA desaturase 1 suppresses diet-induced hyperphagia and hepatic lipid accumulation through PPARα activation and ketone body signaling.

The Journal of biological chemistry·2026

Computational Design and Theoretical Evaluation of Novel Heterocyclic Energetic Materials Based on 5-H-Imidazo-[4,5-c]-Pyridazine and 1,2,4-Triazolo-[4,3-a]-Pyrazine Scaffolds.

Journal of computational chemistry·2026

Dimerization and Ligand Binding Rewire Allosteric Networks in SARS-CoV-2 Main Protease.

Biophysical journal·2026

DyProL: Dynamic Ensemble Representation Learning for Protein-Nucleic Acid Binding Site Prediction.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics-Based Optimization with Limited Activity Data.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

[Construction and application of organoid models in traditional Chinese medicine research].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026

Similarity-Adaptive interaction routing for Drug-Target affinity prediction.

Journal of biomedical informatics·2026

Related Experiment Videos

Binding and kinetic studies of liver alcohol dehydrogenase-coenzyme-pyrazole complexes

Related Concept Videos

Resolution of Michaelis complex, acylation, and conformational change steps in the reactions of the serpin, plasminogen activator inhibitor-1, with tissue plasminogen activator and trypsin.

The distal hinge of the reactive site loop and its proximity: a target to modulate plasminogen activator inhibitor-1 activity.

Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.

Accelerated conversion of human plasminogen activator inhibitor-1 to its latent form by antibody binding.

Inhibitory mechanism of serpins: loop insertion forces acylation of plasminogen activator by plasminogen activator inhibitor-1.

Characterization of the binding of different conformational forms of plasminogen activator inhibitor-1 to vitronectin. Implications for the regulation of pericellular proteolysis.

The BAIAP2 Pathway Regulates Proliferation and Migration in Medulloblastoma.

Targeting PGAM1 Y119 Phosphorylation Resensitizes Non-Small Cell Lung Cancer to Cisplatin Therapy by Promoting Oxidative Stress and DNA Damage.

M6PR/IGF2R double-knockout supplies therapeutic sources for mucolipidosis II and Niemann-Pick C2.

ZBTB38 requires an extended N-terminal zinc finger network to read mCpG- and discriminate TpG-containing DNA sequences.

In vitro reconstitution implicates multiple OMP assembly factors in CdiAEC93 toxin delivery.

Hepatic stearoyl-CoA desaturase 1 suppresses diet-induced hyperphagia and hepatic lipid accumulation through PPARα activation and ketone body signaling.

Computational Design and Theoretical Evaluation of Novel Heterocyclic Energetic Materials Based on 5-H-Imidazo-[4,5-c]-Pyridazine and 1,2,4-Triazolo-[4,3-a]-Pyrazine Scaffolds.

Dimerization and Ligand Binding Rewire Allosteric Networks in SARS-CoV-2 Main Protease.

DyProL: Dynamic Ensemble Representation Learning for Protein-Nucleic Acid Binding Site Prediction.

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics-Based Optimization with Limited Activity Data.

[Construction and application of organoid models in traditional Chinese medicine research].

Similarity-Adaptive interaction routing for Drug-Target affinity prediction.

Related Experiment Videos

Binding and kinetic studies of liver alcohol dehydrogenase-coenzyme-pyrazole complexes

Related Concept Videos

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