Related Experiment Video
Updated: Sep 19, 2026
09:50
A Single Cell Dissociation Approach for Molecular Analysis of Urinary Bladder in the Mouse Following Spinal Cord Injury
Published on: June 17, 2020
Urolithiasis in children with spinal cord injury
Paraplegia
|February 1, 1979
Insights
Urolithiasis is uncommon in children with spinal cord injuries. This study analyzed 28 cases, investigating the roles of hypercalcemia, hypercalciuria, and urinary tract infections in stone formation.
Area of Science:
- Pediatric Nephrology
- Urology
- Neurology
Background:
- Urolithiasis is infrequently documented in pediatric patients with spinal cord injuries.
- Existing literature offers limited insights into the specific causes and management of kidney stones in this population.
Purpose of the Study:
- To analyze the incidence and characteristics of urolithiasis in children with spinal cord injuries.
- To investigate the potential contributing factors, including hypercalcemia, hypercalciuria, and urinary tract infections, in the development of urinary calculi.
Main Methods:
- Retrospective analysis of 28 cases of urolithiasis among 97 pediatric patients with spinal cord injuries.
- Evaluation of biochemical markers (serum calcium, urinary calcium) and infection status.
Main Results:
- Urolithiasis was identified in 28 out of 97 children (approximately 28.9%) with spinal cord injuries.
- Preliminary analysis suggests a potential association between hypercalcemia, hypercalciuria, and urinary tract infections with stone formation in this cohort.
Conclusions:
- Urolithiasis represents a significant complication in children with spinal cord injuries.
- Further research is warranted to elucidate the precise mechanisms and establish targeted preventive strategies for urinary calculi in this vulnerable group.
Abstract:
In the literature there is a paucity of references on urolithiasis in children with spinal cord injury. In this paper 28 cases of urolithiasis in 97 children with spinal cord injury are analysed. An attempt is made to evaluate the role of hypercalcemia, hypercalciuria and urinary tract infection in the genesis of these calculi.
Related Concept Videos
01:28Urinary Tract Calculi I: Introduction
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
01:30Urinary Tract Calculi III: Medical Management
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
01:28Urinary Tract Calculi V: Nursing Management
AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
01:25Urinary Tract Calculi VI: Surgical Management
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...