A curve-fitting procedure for the study of the binding of small molecules to multi-subunit proteins

A small-molecule modulator of poly-alpha 2,8-sialic acid expression on cultured neurons and tumor cells.

Science (New York, N.Y.)·2001

Propagating conformational changes over long (and short) distances in proteins.

Proceedings of the National Academy of Sciences of the United States of America·2001

Structural basis for a change in substrate specificity: crystal structure of S113E isocitrate dehydrogenase in a complex with isopropylmalate, Mg2+, and NADP.

Biochemistry·2001

Redesigning the substrate specificity of an enzyme: isocitrate dehydrogenase.

Biochemistry·2000

Biosynthetic incorporation of unnatural sialic acids into polysialic acid on neural cells.

Glycobiology·2000

Sites of binding and orientation in a four-location model for protein stereospecificity.

IUBMB life·2000

[Spectral and thermal characterization of cephalosporins. I. Cefadroxil and cefalexin].

Il Farmaco; edizione scientifica·1988

Synthesis and antimicrobial activity of some pyrrole derivatives. III--2-(4-arylpiperazino)-3-ethoxycarbonyl-5-aryl-pyrrole derivatives.

Il Farmaco; edizione scientifica·1988

[Synthesis, antisecretory, and anti-ulcer activity of new 5-arylidene-2-ureidoalkyl-3-pyridazinones].

Il Farmaco; edizione scientifica·1988

3,5-Diphenyl-1H-pyrazole derivatives. II--N-substituted 1-(2-aminoethyl)-3,5-diphenyl-1H-pyrazoles and their 4-bromo derivatives with analgesic and other activities.

Il Farmaco; edizione scientifica·1988

How medicinal chemistry triggers fundamental research in heterocyclic chemistry. The chemistry of 4-hydroxy-2-pyrones and a new imidazole antifungal agent.

Il Farmaco; edizione scientifica·1988

S-Aryl(tetramethyl)isothiouronium salts as possible antimicrobial agents--III.

Il Farmaco; edizione scientifica·1988

Lead Optimization of Multimutant KRAS Switch-II Pocket Macrocyclic Inhibitors via Isosteric Replacement to Improve ADME and Oral Exposure.

Journal of medicinal chemistry·2026

HighMorph: De Novo Cyclic Peptide Sequence Design via Protein-Protein Interaction Recapitulation.

Journal of medicinal chemistry·2026

Design and Synthesis of Anemoside B4 Derivatives as Pyruvate Carboxylase-Targeting Therapeutic Agents for Atopic Dermatitis.

Journal of medicinal chemistry·2026

Structure-Based Design of First Ndc80 Loop-Targeting Peptide Disrupting Ndc80-Nuf2 Interaction for Hepatocellular Carcinoma Therapy.

Journal of medicinal chemistry·2026

CoCoBind: Consistency-Contrastive Multitask Learning for RNA-Ligand Interaction and Binding Site Prediction.

Journal of medicinal chemistry·2026

Chemical Stabilization and Transformation of Schiff Base Scaffold: A Path toward Superior Platinum-Based Anti-Cancer Stem Cell Drugs.

Journal of medicinal chemistry·2026

Related Experiment Videos

A curve-fitting procedure for the study of the binding of small molecules to multi-subunit proteins

Related Concept Videos

A small-molecule modulator of poly-alpha 2,8-sialic acid expression on cultured neurons and tumor cells.

Propagating conformational changes over long (and short) distances in proteins.

Structural basis for a change in substrate specificity: crystal structure of S113E isocitrate dehydrogenase in a complex with isopropylmalate, Mg2+, and NADP.

Redesigning the substrate specificity of an enzyme: isocitrate dehydrogenase.

Biosynthetic incorporation of unnatural sialic acids into polysialic acid on neural cells.

Sites of binding and orientation in a four-location model for protein stereospecificity.

[Spectral and thermal characterization of cephalosporins. I. Cefadroxil and cefalexin].

Synthesis and antimicrobial activity of some pyrrole derivatives. III--2-(4-arylpiperazino)-3-ethoxycarbonyl-5-aryl-pyrrole derivatives.

[Synthesis, antisecretory, and anti-ulcer activity of new 5-arylidene-2-ureidoalkyl-3-pyridazinones].

3,5-Diphenyl-1H-pyrazole derivatives. II--N-substituted 1-(2-aminoethyl)-3,5-diphenyl-1H-pyrazoles and their 4-bromo derivatives with analgesic and other activities.

How medicinal chemistry triggers fundamental research in heterocyclic chemistry. The chemistry of 4-hydroxy-2-pyrones and a new imidazole antifungal agent.

S-Aryl(tetramethyl)isothiouronium salts as possible antimicrobial agents--III.

Lead Optimization of Multimutant KRAS Switch-II Pocket Macrocyclic Inhibitors via Isosteric Replacement to Improve ADME and Oral Exposure.

HighMorph: De Novo Cyclic Peptide Sequence Design via Protein-Protein Interaction Recapitulation.

Design and Synthesis of Anemoside B4 Derivatives as Pyruvate Carboxylase-Targeting Therapeutic Agents for Atopic Dermatitis.

Structure-Based Design of First Ndc80 Loop-Targeting Peptide Disrupting Ndc80-Nuf2 Interaction for Hepatocellular Carcinoma Therapy.

CoCoBind: Consistency-Contrastive Multitask Learning for RNA-Ligand Interaction and Binding Site Prediction.

Chemical Stabilization and Transformation of Schiff Base Scaffold: A Path toward Superior Platinum-Based Anti-Cancer Stem Cell Drugs.

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A curve-fitting procedure for the study of the binding of small molecules to multi-subunit proteins

Related Concept Videos

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