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Preliminary bioavailability study on protacine: a new, non-steroidal anti-inflammatory agent
Current Medical Research and Opinion
|January 1, 1979
Summary
Protacine absorption and elimination half-lives were determined in healthy volunteers. Results suggest protacine is suitable for long-term maintenance treatment.
Area of Science:
- Pharmacokinetics
- Clinical Pharmacology
Background:
- Protacine is an orally administered drug.
- Understanding its pharmacokinetic profile is crucial for effective dosing.
Purpose of the Study:
- To determine the pharmacokinetic parameters of protacine after a single oral dose.
- To evaluate the suitability of protacine for maintenance therapy.
Main Methods:
- Healthy volunteers received a single oral dose of 600 mg protacine.
- Blood samples were analyzed using high-pressure liquid chromatography.
- Pharmacokinetic analysis was performed using a two-compartment open model.
Main Results:
- Peak protacine blood concentration was observed at 8 hours post-administration.
- The absorption half-life was determined to be 3.4 hours.
- The elimination half-life was found to be 10 hours.
Conclusions:
- The pharmacokinetic profile supports a potential maintenance treatment regimen of 150 mg twice daily.
- Protacine appears well-suited for long-term therapeutic use beyond acute conditions.