Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synaptic electrogenesis in eel electroplaques.

F Ruiz-Manresa, H Grundfest

    The Journal of General Physiology
    |January 1, 1971
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Contributions of various ions to the resting and action potentials of crayfish medial giant axons.

    The Journal of membrane biology·2013
    Same author

    Damage to peripheral nerves by high velocity missiles without a direct hit.

    Journal of neurosurgery·2010
    Same author

    The origin of electrical activity from spinal afferent stimulation of the inferior olive of cats.

    Federation proceedings·2010
    Same author

    Effect of di-isopropyl fluorphosphate on action potential and choline esterase of nerve.

    Journal of neurophysiology·2010
    Same author

    Generality of the role of acetylcholine in nerve and muscle conduction.

    Journal of neurophysiology·2010
    Same author

    Effect of di-isopropyl fluorphosphate (DFP) on action potential and cholinesterase of nerve, II.

    Journal of neurophysiology·2010
    Same journal

    Conformational changes upon pore blocker removal reveal conductive states of TMEM16A.

    The Journal of general physiology·2026
    Same journal

    On the mechanism of hypomagnesemia with treatment-resistant seizures caused by variants of the Na+,K+-ATPase α1 subunit (ATP1A1).

    The Journal of general physiology·2026
    Same journal

    Label-free real-time imaging of mitochondrial matrix volume changes and permeability transition in living cells.

    The Journal of general physiology·2026
    Same journal

    Differential regulation of β1-dependent voltage shifts and kinetic modulation by an extracellular glutamate in NaV1.6 VSDIV.

    The Journal of general physiology·2026
    Same journal

    Mechanistic insights into DCPIB inhibition of VRAC: Electrostatic control and binding plasticity.

    The Journal of general physiology·2026
    Same journal

    An epilepsy-associated KV3.1 potassium channel variant acts via dominant-positive effect.

    The Journal of general physiology·2026
    See all related articles

    Synaptic activation in eel electroplaques increases conductance for sodium (Na) and potassium (K) ions. This ion flow generates a voltage signal, demonstrating electrical excitability in synaptic components.

    Area of Science:

    • Neuroscience
    • Electrophysiology
    • Biophysics

    Background:

    • Eel electroplaques are model systems for studying synaptic transmission and electrical excitability.
    • Synaptic membranes generate electrical signals through changes in ion conductance.

    Purpose of the Study:

    • To investigate the ionic mechanisms underlying synaptic electrogenesis in eel electroplaques.
    • To characterize the reversal potential and conductance changes during synaptic activation.

    Main Methods:

    • Electrophysiological recordings from eel electroplaques.
    • Manipulating extracellular ionic concentrations (Na, K, Ca, Mg).
    • Voltage-clamp analysis to determine ionic conductances and reversal potentials.

    Main Results:

    Related Experiment Videos

    • Synaptic activation increases conductance for both Na and K ions (G(SSNa) and G(SSK)) with a ratio near unity.
    • The synaptic reversal potential (E(S)) is consistently inside-positive, between Na and K equilibrium potentials.
    • Synaptic potassium conductance (G(SSK)) is independent of external Na and electrically excitable K channels.
    • The synaptic membrane exhibits slight permeability to Ca and Mg ions.
    • Synaptic conductance decreases with depolarization, showing electrical excitability and inactivation.

    Conclusions:

    • Synaptic electrogenesis in eel electroplaques is mediated by a balanced increase in Na and K conductance.
    • The synaptic membrane displays electrical excitability, similar to nonsynaptic components, with voltage-dependent inactivation.