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Synthesis of some newer piperazinoquinazolones as cardiovascular agents
Die Pharmazie
|January 1, 1979
Abstract:
Twenty nine new substituted 2-methyl-3-(gamma-piperazino-propiophenyl)-4-quinazolone hydrochlorides were synthesised by the Mannich reaction of substituted quinazolones with substituted piperazines and evaluated for their cardiovascular activity. Several compounds of the series exhibited marked and sustained hypotensive activity.