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Neuropathy associated with lymphoma.

J C Walsh

    Journal of Neurology, Neurosurgery, and Psychiatry
    |February 1, 1971
    PubMed
    Summary
    This summary is machine-generated.

    Malignant lymphoma can cause peripheral neuropathy, affecting nerve conduction in 35% of patients. Nerve biopsies reveal axonal degeneration and demyelination in myelinated fibers, but not unmyelinated ones.

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    Area of Science:

    • Neurology
    • Oncology
    • Pathology

    Background:

    • Malignant lymphoma is a cancer of the lymphatic system.
    • Peripheral neuropathy is a common complication of various medical conditions.

    Purpose of the Study:

    • To investigate the presence and nature of peripheral neuropathy in patients with malignant lymphoma.
    • To compare electrophysiological findings in lymphoma patients with age-matched controls.

    Main Methods:

    • Electrophysiological studies were conducted on 62 lymphoma patients and 35 controls.
    • Sural nerve biopsies were performed on five patients for histological and electronmicroscopic examination.

    Main Results:

    • Electrophysiological evidence of peripheral neuropathy was found in 22 (35%) lymphoma patients.

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  • Nerve biopsies showed axonal degeneration and segmental demyelination of myelinated fibers.
  • Unmyelinated nerve fibers were unaffected in the studied patients.

    • Conclusions:

    • Peripheral neuropathy is a significant electrophysiological finding in a substantial proportion of malignant lymphoma patients.
    • The neuropathy is characterized by axonal degeneration and demyelination of myelinated nerve fibers.
    • These findings suggest a direct or indirect effect of lymphoma on peripheral nerve structure and function.