The influence of chlordimeform on calcium and glucose homeostasis

The effects of single and repeated administration of chlordimeform on calcium and glucose homeostasis were examined in the rat. A single injection of chlordimeform (100 mg/kg, i.p.) produced a rapid 15 percent decrease in plasma calcium and a 64 percent rise in plasma glucose. The administration of chlordimeform (75 mg/kg, i.p., twice daily) over a period of 7 days caused an 8 percent reduction in plasma calcium, a 50 percent decrease in duodenal calcium transport and a 20 percent decrease in body weight.